Studying the effect of polypill in the prevention of chronic diseases. In Iran, preventing incidence of chronic diseases in high risk people is one of the health priorities. Strategies for primary prevention include decreasing risk factors (hypertension, dyslipidemia, and diabetes) and administering controlling medication. In this regard, instead of separate medications a combination of them have been developed named as polypill which is currently examined on individuals over 50 in Golestan Cohort Study.
As gastric cancer is asymptomatic in preliminary stages, most of patients who present with clinical symptoms of gastric cancer have advanced and incurable gastric cancer. Therefore, appropriate options to decrease the mortality rate secondary to gastric cancer are restricted to screening or fighting with its etiologic risk factors. In this regard, information on factors such as Helicobacter Pylori infection and dietary and genetic etiologies can help attain the best strategy to fight with gastric cancer.
Esophageal Squamous Cell Carcinoma (SCC) with 5-year survival rate between 5-10% in the symptomatic stage is among most fatal cancers. Several hypotheses in this regard have been suggested including the role of genetic, dietary, health, and environmental factors. To assess the validity of these hypotheses, a cohort study is ongoing with the collaboration of Golestan University of Medical Sciences, International Agency for Research on Cancer, and National Cancer Institute.